Tablet, Cream and for Serving Azelaic Acid.
Azelaic acid is a saturated, unbranched dicarboxylic acid: 1,7-heptandicarboxylic acid (nonanedioic acid). The antibacterial effect is demonstrated by the decrease of the bacterial colonization in the cutaneous surface and inside the follicle, as well as by a reduction of the percentage of free fatty acids in the lipids of the cutaneous surface. It exerts a direct comedolitic effect on the efflorescence that influences the differentiation of keratinocytes and, possibly, their proliferation, which allows a normalization of disturbed follicular keratinization. The effective pharmacological action is based on its easy penetration into the skin. As a small part of the acid applied topically is absorbed percutaneously, biotransformation and elimination should also be considered as important pharmacokinetic parameters. Under clinical conditions, including application to large surfaces, they can not be used, in general, more than 6g per day. This equates to a systemic reabsorption of 44mg of azelaic acid. Taking into account daily elimination rates of 18 to 28mg in untreated healthy volunteers, which respond to an endogenous amount of 30 to 47mg / day, the calculated systemic overload is very low, in particular, considering the generally non-toxic properties of azelaic acid. Different forms of acne vulgaris, that is, inflammatory and non-inflammatory forms. Apply the cream 2 times a day (morning and evening) via Healthknowing , in abundant amount, on the affected skin areas, massaging enough to penetrate the skin. In general, an improvement is observed, manifested after 4 weeks of treatment. They may occur occasionally, usually at the start of therapy, local irritations eg flushing or peeling, as well as itching and burning that will certainly decrease during the course of treatment.
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Azelaic acid is for external use only.Eye penetration should be avoided;if carelessness occurs, they should be washed afterwards, with care and abundant water.The product should not be kept at a temperature higher than the ambient temperature.